Altertoxins with potent anti-HIV activity from Alternaria tenuissima QUE1Se, a fungal endophyte of Quercus emoryi
نویسندگان
چکیده
منابع مشابه
Altertoxins with potent anti-HIV activity from Alternaria tenuissima QUE1Se, a fungal endophyte of Quercus emoryi.
Screening of a small library of natural product extracts derived from endophytic fungi of the Sonoran desert plants in a cell-based anti-HIV assay involving T-cells infected with the HIV-1 virus identified the EtOAc extract of a fermentation broth of Alternaria tenuissima QUE1Se inhabiting the stem tissue of Quercus emoryi as a promising candidate for further investigation. Bioactivity-guided f...
متن کاملTenuazonic acid production by Alternaria alternata and Alternaria tenuissima isolated from cotton.
Cultures of Alternaria alternata (three isolates) and Alternaria tenuissima (three isolates) obtained from cottonseeds and bolls were toxigenic when cultured on various laboratory media. A mycotoxin was isolated and identified as tenuazonic acid by using solvent partition, thin-layer chromatography, and instrument analyses. Toxicity was monitored with brine shrimp and chicken embryo bioassays. ...
متن کاملA highly pure sub-fraction of shallot extract with potent in vitro anti-angiogenic activity
Abstract Our previous studies showed that various extracts of Persian shallot (Allium hirtifolium) have anti-angiogenic effects. This study has been undertaken to isolate and identify the major effective anti-angiogeneic sub-fraction of shallot. After preparation of the 50% hydroalcoholic extract of shallot bulbs, the extract was successively fractionated into n-hexane, ethyl acetate, n-butanol...
متن کاملPilot-plant production of protease by Alternaria tenuissima.
Agar slants of a selected Alternaria tenuissima strain were illuminated to give conidia suitable for further propagation. For production of protease with an optimal caseolytic activity in the region of pH 8 to 10, the fungus was cultivated in steel fermentors with 6- and 60-liter working capacity. Maximal activity, 1.5 enzyme units per liter, was attained in a medium based on liver after about ...
متن کاملBioactive secondary metabolites with multiple activities from a fungal endophyte
In order to replace particularly biohazardous nematocides, there is a strong drive to finding natural product-based alternatives with the aim of containing nematode pests in agriculture. The metabolites produced by the fungal endophyte Fusarium oxysporum 162 when cultivated on rice media were isolated and their structures elucidated. Eleven compounds were obtained, of which six were isolated fr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2014
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2014.08.039